孕期慢性间歇性缺氧会引发母亲的炎症,并破坏胎盘应激反应
Jennifer J Gardner1,2, Reneé de Nazaré Oliveira da Silva3, Jessica L Bradshaw2
1Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, United States.
晚期妊娠慢性间歇性缺氧 (CIH) 在大鼠中增加母体炎症和改变胎盘应激反应,降低胎盘效率而不影响胎儿生长. 这突出了怀孕后期的脆弱性,为缺氧相关的并发症提供了目标.
科学领域:
- 生殖生物学 生殖生物学
- 围产儿医学 围产儿医学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 孕期缺氧与胎盘氧化应激和炎症有关.
- 在细胞外囊泡 (EVs) 中循环的无细胞线粒体DNA (ccf-mtDNA) 可以促进炎症.
- 妊娠晚期慢性间歇性缺氧 (CIH) 对母亲和胎盘应激反应的影响需要进一步调查.
研究的目的:
- 研究CIH在怀孕晚期对母体炎症,EV特征和小鼠胎盘应激反应的影响.
- 为了确定CIH是否会改变循环中的ccf-mtDNA,EV相关的mtDNA (EV-mtDNA) 和母细胞因子概况.
- 为了评估妊娠CIH暴露后的胎盘抗氧化,亡和自路径.
主要方法:
- 怀孕的老鼠从15-20个妊娠日开始暴露于CIH或normoxia.
- 使用RT-qPCR对ccf-mtDNA和EV-mtDNA进行量化.
- 测量与应激反应相关的母细胞因子,氧化应激 (AOPPs) 和胎盘基因/蛋白质表达.
主要成果:
- CIH增加了胎盘体重和降低了胎盘效率,但没有影响胎儿生物识别.
- EV度下降,这表明每次EV的EV-mtDNA增加,而母体IL-18增加.
- 胎盘抗氧化基因 (catalase, sod2) 和自蛋白 (Beclin-1, p62) 的高调.
结论:
- 在怀孕后期的妊娠CIH破坏了母亲的EV形状和炎症,降低了胎盘效率,并调节了胎盘抗氧化和自机制.
- 这些影响在不影响胎儿生长的情况下发生,这表明孕期晚期母亲与胎儿之间存在特定的脆弱性.
- 结果确定了理解和管理低氧相关妊娠并发症的潜在目标.
更多相关视频
05:31Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
08:50A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
相关概念视频
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Asthma-I: Introduction
Teratogenicity
Hypothalamic-Pituitary Axis
Transcytosis of IgG
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
