验证西班牙语版本的COGNITO作为与多发性硬化症相关的认知障碍的评估工具
Nieves Revert-Alcántara1, María Jesús Funes2, Carmen Sáez-Zea3
1San Rafael University Hospital, Granada, Spain.
The Clinical neuropsychologist
|July 21, 2025
概括
计算机化信息处理评估电池 (COGNITO) 能够有效地检测到西班牙多发性硬化症患者的认知障碍. 这种可靠的工具有助于早期诊断,并改善了MS患者的生活质量.
科学领域:
- 神经学 神经学
- 神经心理学 神经心理学
- 医疗技术 医疗技术 医学技术
背景情况:
- 多发性硬化症 (MS) 通常会导致认知障碍 (CI),影响患者的生活质量.
- 由于缺乏针对西班牙人口的验证评估工具,MS中的CI往往被诊断不足.
- 早期发现IC对于MS的及时干预和管理至关重要.
研究的目的:
- 分析计算机化信息处理评估电池 (COGNITO) 的可靠性和有效性,用于评估西班牙MS患者的CI.
- 为了评估COGNITO的诊断准确性,与金色标准的神经心理电池相比.
- 确定COGNITO在区分有CI和没有CI的MS患者中的实用性.
主要方法:
- 一项多中心研究涉及64名多发性硬化患者 (25名没有CI,39名有CI) 和183名西班牙的健康对照.
- 参与者完成了COGNITO触摸屏电池和简要的神经心理电池 (BNB) 作为黄金标准.
- 统计分析包括组间比较和使用曲线下的面积 (AUC) 评估一致性,灵敏度和特异性的评估.
主要成果:
- 认知分数显示了统计学上显著的正相关性与BNB评估的CI.
- 在区分具有CI的MS患者时,COGNITO表现出高的诊断准确性 (AUC = 0.97),灵敏度 (0.97),和特异性 (0.78).
- 该工具有效地区分了健康对照组和经历认知障碍的MS患者.
结论:
- COGNITO是一种可靠且有效的工具,用于早期检测西班牙MS患者的认知障碍.
- 基于触摸屏的电池具有很高的诊断实用性和在临床实践中强大的适用性.
- 使用COGNITO可以促进及时诊断和管理,从而有可能改善MS患者的治疗结果.
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