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单价XBB.1.5COVID-19疫苗的有效性:一个系统的审查和元分析

Hsin Ma¹, Yi-Yu Chen², Wei-Liang Shih³

¹Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

|July 21, 2025

概括

在JN.1变种出现之前,单价XBB.1.5疫苗对严重的COVID-19结果提供了显著的保护. 更新的疫苗接种对于维持对新型SARS-CoV-2菌株的防御至关重要.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
公共卫生公共卫生

背景情况:

尽管2019年新冠病毒病 (COVID-19) 已经结束了其流行病地位,但它仍然是一个令人担忧的问题,XBB是主要的SARS-CoV-2变种.
人口免疫水平对当前单价XBB.1.5疫苗的有效性提出了疑问.

研究的目的:

在2023-2024赛季期间评估单价XBB.1.5COVID-19疫苗在成年人中的有效性.
评估疫苗对感染,住院和死亡的有效性 (VE).
分析 VE 趋势随着时间的推移,以及与新兴变种 (如 JN.1.1) 相比.

主要方法:

在2024年11月30日之前发表的研究的系统审查,来源于PubMed,Embase,Web of Science和Cochrane Central.
包括21项研究,超过5300万参与者.
进行了随机效应模型元分析.

主要成果:

针对感染,住院和死亡的初始VE分别为52.9%,64.4%和77.3%,在第五个月下降.
对JN.1变种的有效性显著下降:感染率为47%,住院率为32%,死亡率为26%.
在60岁以上和60岁以下的个体中,对住院治疗的 VE 是可比的.

结论:

在JN.1变种占主导地位之前,XBB.1.5疫苗对严重的COVID-19提供了实质性的保护.
该研究强调了更新COVID-19疫苗的必要性,以应对不断演变的SARS-CoV-2变种并保持公共卫生保护.

关键词:

关于COVID-19疫苗的使用情况这就是SARS-CoV-2病毒.疫苗的有效性疫苗的有效性

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