对食道粘膜活检样本的重新评估显示了脱
Selda Karaaslan1, Lihui Qin1, Erika Hissong1
1Department of Pathology and Laboratory Medicine, New York-Presbyterian Hospital/Weill Cornell Medicine, New York, NY, USA.
Histopathology
|July 21, 2025
概括
食道内膜的脱落可以发生在有或没有炎症的情况下,称为脱落食道病或食道炎. 这种食道损伤模式与药物使用有关,特别是鼻腔/吸入皮质类固醇.
科学领域:
- 胃肠病学 胃肠病学
- 组织病理学 组织病理学
- 消化道疾病 消化道疾病
背景情况:
- 食道状粘膜的松动是一种在各种条件下观察到的组织学发现,有或没有炎症.
- 了解 oesophageal sloughing 的不同原因和临床影响对于准确的诊断和管理至关重要.
研究的目的:
- 为了比较胰腺组织学,内镜和临床发现,患有食道脱的患者,区分有炎症和没有炎症的病例.
- 分析患有 oesophageal sloughing 的患者的药物史.
主要方法:
- 对51个食道活检样本进行了回顾性分析,分为脱落食道病变 (没有炎症) 或脱落食道炎 (有炎症).
- 包括细菌和真菌污染,以及从确定的食道炎患者中对控制食道活检的前性评估.
- 组间内镜检查结果和药物治疗史的比较.
主要成果:
- 在这两组中,流动性病变主要发生在食道中部 (67%).
- 在食道病症组内,内镜排泄和鼻腔/吸入皮质类固醇的使用显著高于食道病症组 (分别为55%与22%和38%与10%).
- 在73%的食道炎病例中,细菌被发现在脱离的上皮上,这表明殖民而不是感染;在对照食道炎活检中没有观察到脱落.
结论:
- 食道状粘膜的松动是一种可以在有或没有炎症的情况下识别的组织学特征 (食道病变与食道炎).
- 中 oesophageal 占主导地位和与多种药物的关联表明药物诱导的食道损伤是这种损伤模式的重要因素.
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