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Updated: Sep 14, 2025

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通过ubiquitin激活SPRTN蛋白酶的Allosteric激活维持了基因组的稳定性

Sophie Dürauer1,2, Hyun-Seo Kang3,4, Christian Wiebeler5

  • 1Gene Center, Ludwig-Maximilians-Universität München, Munich, Germany.

Nature communications
|July 21, 2025
PubMed
概括

对于基因组稳定至关重要的DNA依赖蛋白酶SPRTN,通过DNA-蛋白质交叉链接 (DPCs) 的ubiquitin修饰来激活. 这种精确的调节可以防止基因组不稳定性和相关疾病.

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