饮食:超越营养和能源供应
1Protein Science Key Laboratory of the Ministry of Education, School of Pharmaceutical Sciences,Tsinghua University, Beijing, 100084, PR China.
NPJ science of food
|July 21, 2025
概括
这项研究将低剂量食物压力因素对健康的有益影响hormesis引入食品科学. 它提出了一个新的功能性食品的评估系统,基于hormesis和剂量反应关系.
科学领域:
- 食品科学与营养 食品科学与营养
- 细胞生物学 细胞生物学
- 毒理学 毒理学 毒理学
背景情况:
- 传统的研究重点是食品的营养和能量含量.
- 低剂量压力因素的有益影响hormesis的概念在食品科学中经常被忽视.
- 植物代谢物,发酵和产生可以充当压力源的化合物.
研究的目的:
- 阐明霍梅西斯在食品科学中的作用及其对健康的影响.
- 为了检查食物衍生的压力因素如何调节细胞防御网络.
- 提出一种新的基于剂量反应的双相食品评价系统.
主要方法:
- 在食品科学中对hormesis的文献综述.
- 对植物代谢物,发酵产品和副产品的分析.
- 一个双相剂量反应评估系统的概念框架.
主要成果:
- 霍尔梅西斯在调解食品成分对健康的影响方面发挥着重要作用.
- 来自食物的化合物可以通过hormesis激活细胞防御机制.
- 双相剂量反应模型可以更好地评估食物对健康的影响.
结论:
- 荷尔梅斯是理解食物对健康的益处的关键因素.
- 需要转向精准营养和hormesis驱动的功能性食品开发的范式转变.
- 拟议的评估系统可以指导开发更健康的食品.
相关概念视频
Regulation of Metabolism
9.9K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
9.9K
Target Cell Response to Hormones
3.6K
Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
3.6K
Hormonal Regulation
44.5K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
44.5K
Feedback Loops
58.6K
In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
58.6K
Regulation of Hormone Secretion
4.1K
Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
Humoral...
4.1K
Functions of Thyroid Hormones
3.2K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
3.2K


