美国成年人中C反应性蛋白-甘油三糖指数和心力衰竭从NHANES 2001-2010年
Ningyi Cheng1,2, Zhicheng Ma3, Yukun Chen1,2
1Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
Scientific reports
|July 21, 2025
概括
C反应蛋白 (CRP) - 三甘油糖指数 (CTI) 与心力衰竭 (HF) 的更高患病率有关. 这项研究表明,CTI可以作为一种有价值的生物标志物,用于识别高频风险人群.
科学领域:
- 心血管医学 心血管医学
- 生物标志物 生物标志物
- 代谢综合征是代谢综合征的一种.
背景情况:
- 心力衰竭 (HF) 是一个重要的全球健康问题,发病率和死亡率不断上升.
- C反应蛋白 (CRP) - 三甘油糖指数 (CTI) 是一种用于炎症和胰岛素抵抗的新型复合生物标志物.
- CTI和HF之间的关联尚未被彻底研究.
研究的目的:
- 调查C反应蛋白 (CRP) - 三甘油糖指数 (CTI) 与美国成年人心力衰竭 (HF) 患病率之间的关系.
主要方法:
- 对2001-2010年国家健康和营养检查调查 (NHANES) 的21,974名参与者的横截面分析.
- 基于自我报告的病史进行HF诊断.
- 使用多变量逻辑回归,平滑曲线拟合和子组分析来评估关联和剂量反应关系.
主要成果:
- 与没有HF的人相比,患有HF的人的CTI水平显著更高 (p < 0.001).
- 在CTI水平和HF患病率之间观察到正相关性 (p < 0.001).
- 调整后勤回归显示,HF与较高CTI的几率比率增加,表明非线性剂量反应关系,值为11.657.
结论:
- C反应蛋白 (CRP) - 三甘油糖指数 (CTI) 与美国成年人心力衰竭的存在有关.
- CTI可能具有作为心力衰竭预防和管理策略的预测生物标志物的潜力.
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