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Updated: Sep 14, 2025

Assays for Validating Histone Acetyltransferase Inhibitors
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Assays for Validating Histone Acetyltransferase Inhibitors

Published on: August 6, 2020

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向KAT8可通过调节牛皮的h4 lysine 16乙化调节,缓解自身RNA驱动的皮肤炎症

Yan Xiang1,2, Yuyu Jiang1,2, Zeting Wang1,2

  • 1National Key Laboratory of Immunity & Inflammation, Naval Medical University, Shanghai, China.

Cell death and differentiation
|July 21, 2025
PubMed
概括

这项研究表明,自我RNA通过通过TLR7通路激活巨细胞来驱动牛皮的炎症. 针对巨细胞中的KAT8和H4K16ac表观遗传修饰,为牛皮提供了一个有希望的治疗策略.

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Histone Modification02:32

Histone Modification

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Chromatin Modification in iPS Cells

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Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
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Covalently Linked Protein Regulators

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