在中国健康的老年人中,与衰老相关的GFR下降
Qiaojing Qin1,2, Xiaoyan Chen3, Yong Gu1,4
1Department of Nephrology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, 200240, China.
International urology and nephrology
|July 21, 2025
概括
通过估计的膜过率 (eGFR) 测量功能,在健康的中国老年人中随着年龄的增长而下降. 这种下降平均每年近1毫升/分钟/1.73平方米,不受性别的影响.
科学领域:
- 老年学是一门学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 公共卫生 公共卫生
背景情况:
- 衰老与功能自然下降有关.
- 了解估计的淋巴细胞过率 (eGFR) 与年龄相关的变化对于区分正常衰老和疾病引起的衰退至关重要.
- 健康老龄化人口需要特定的数据来确定规范性功能值.
研究的目的:
- 为了确定65岁以上健康的中国人的eGFR下降率.
- 为了确定这个人口群体中与年龄相关的正常eGFR变化的基线.
- 为了区分正常的衰老和病态的功能下降.
主要方法:
- 来自中国上海的5375名健康老年人 (≥65岁) 的分析.
- 排除患有影响功能疾病的参与者 (糖尿病,高血压等). ) 的情况.
- 多变量线性回归用于评估eGFR随年龄和性别的变化.
主要成果:
- 在所有组中,平均eGFR随着年龄的增长显著下降.
- 健康的老年人始终表现出高于不健康的人的EGFR.
- 在eGFR和年龄之间观察到线性相关性 (回归系数: -0.999 mL/min/1.73 m2/year);性别没有显著影响.
结论:
- 65岁以上的健康中国老年人每年经历的eGFR下降约为1mL/min/1.73m2.
- 这种与年龄相关的衰退是独立于性别的.
- 确定这种规范性下降有助于识别老年人患有病理性功能障碍.
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