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Updated: Sep 14, 2025

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
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mTORC1通过GCN2感知谷氨酸和其他氨基酸

Gianluca Figlia1,2,3,4, Sandra Müller5,6,7, Fabiola Garcia-Cortizo5,6,7

  • 1Signal Transduction in Cancer and Metabolism, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany. gfiglia@ukaachen.de.

The EMBO journal
|July 21, 2025
PubMed
概括

蛋白质激酶GCN2感知着mTORC1的谷氨酸可用性,不是直接,而是通过阿斯巴拉金减少. 这种GCN2通路,以及专门的传感器,使mTORC1能够监测细胞生长调节的各种氨基酸.

关键词:
氨基酸传感器 氨基酸传感器亚斯巴拉基因 (Aspragine) 是一种在 GCN2 中.谷氨胺是一种胺.在 mTORC1 的情况下,mTORC1 是

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