暴露于学术压力的学生的肠道微生物群的益生菌介导调节:一种随机对照试验
Jorge Francisco Vázquez-Castellanos1,2, Lucas Ferreira Maciel1,2, Lucas Wauters3,4
1Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
NPJ biofilms and microbiomes
|July 21, 2025
概括
这项研究发现,Lacticaseibacillus rhamnosus CNCM I-3690 益生菌的消费可以在学术压力期间稳定肠道微生物群. 它与减少焦虑和保持学生的肠道微生物群多样性有关.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
背景情况:
- 益生菌正在研究其对精神健康的影响,但结果各不相同.
- 肠道微生物组的改变可能是益生菌对心理健康的影响的基础.
- 学业压力显著影响学生的幸福感和肠道微生物群.
研究的目的:
- 评估Lacticaseibacillus rhamnosus CNCM I-3690对受学术压力的学生肠道微生物群的影响.
- 调查益生菌摄入量,肠道微生物组变化和压力/焦虑水平之间的关系.
- 探索这种益生菌菌株对应激反应的潜在有益影响.
主要方法:
- 一项为期4周的随机对照试验,涉及学生食用益生菌或对照产品.
- 使用16S rRNA和猎枪元基因组测序进行定量微生物组分析.
- 通过客观和自我报告的措施来评估压力和焦虑.
主要成果:
- 与对照人群相比,L. rhamnosus CNCM I-3690的摄入导致了压力期间下肠道微生物群多样性变化.
- 益生菌菌株影响了特定肠道细菌的丰富性,包括Ruminococcus bicirculans.
- 增加的F. prausnitzii丰富度与自我报告的考试前焦虑的减少相关.
结论:
- L. rhamnosus CNCM I-3690 在调节肠道微生物对心理压力的反应方面显示出潜力.
- 益生菌可能有助于维持肠道微生物的稳定性,并减少压力学生的焦虑.
- 需要进一步的研究来阐明这种益生菌与宿主在压力期间相互作用的精确机制.
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