Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genomics02:02

Genomics

37.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
37.5K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

19.3K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
19.3K
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

4.3K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
4.3K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

6.2K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.2K
Human Genetics01:28

Human Genetics

730
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
730
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

14.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Developing an approach to estimate the number of road traffic crashes at the national level using media-reported data.

Global health research and policy·2026
Same author

Characteristics of media-reported road traffic crashes involving professional delivery e-bike riders versus other e-bike riders in China.

Journal of safety research·2026
Same author

eATP sensing by the purinergic receptor PA2072 for allosteric modulation in intracellular c-di-GMP signaling.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Helmet use among cyclists and motorcyclists involved in media-reported road traffic crashes after implementation of the national 'One Helmet, One Belt' campaign in China.

Journal of epidemiology and community health·2025
Same author

Oxygen regulates proliferation and phenotype in the RS0 SDH-deficient pheochromocytoma cell line.

Endocrine-related cancer·2025
Same author

Ferroptosis-related protein biomarkers for diagnosis, differential diagnosis, and short-term mortality in patients with sepsis in the intensive care unit.

Frontiers in immunology·2025

相关实验视频

Updated: Sep 14, 2025

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

515

通过整合多omics数据来进行人类基本基因预测的深度整体框架.

Xue Zhang1, Weijia Xiao2, Brent Cochran3

  • 1College of Information Science and Engineering, Provincial Key Laboratory of Informational Service for Rural Area of Southwestern Hunan, Shaoyang University, Shaoyang, 422000, China. lindajia03@gmail.com.

Scientific reports
|July 21, 2025
PubMed
概括

我们开发了DeEPsnap,这是一种深度学习方法,用于预测人类的基本基因. 这种方法准确地识别了对生命至关重要的基因,有助于疾病研究和药物开发.

关键词:
深度学习是一种深度学习.基本的基因预测多omics数据集成多omics数据集成快照组合合集 快照组合

更多相关视频

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.3K
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.5K

相关实验视频

Last Updated: Sep 14, 2025

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

515
Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.3K
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.5K

科学领域:

  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学

背景情况:

  • 基本基因对生物体的生存和繁殖至关重要.
  • 了解基因本质性有助于推进基础生命科学,人类疾病研究和药物发现.

研究的目的:

  • 提出DeEPsnap,一种用于预测人类基本基因的新型深度神经网络方法.
  • 整合多样化的生物数据,以提高预测准确度.

主要方法:

  • DeEPsnap使用一个快照集团深度神经网络.
  • 它整合了DNA/蛋白质序列和功能数据 (基因本体学,蛋白质复合体,域,相互作用网络) 的特征.
  • 具有成本敏感性的深度神经网络被训练有超过200个集成的功能.

主要成果:

  • 通过十倍交叉验证,DeEPsnap实现了高预测性能:96.16%的AUROC,93.83%的AUPRC和92.36%的准确性.
  • 对比实验证明了DeEPsnap在传统和其他深度学习模型上的优势.
  • 该方法有效地预测了人类基因的基本性.

结论:

  • DeEPsnap是预测人类基本基因的有效和准确方法.
  • 多种特征类型的集成显著改善了预测.
  • 这种工具在理解基本生物学和开发治疗中具有潜在的应用.