富含BActeroides和Prevotella的肠道微生物集群与代谢风险有关
Yi Rou Bah1, Kairi Baba2, Dayang Nurul Asyiqin Binte Mustafa1
1Lee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Singapore, 308232, Singapore.
Gut pathogens
|July 21, 2025
概括
肠道微生物群的肠道类型会影响代谢健康. 细菌类2 (B2) 和Prevotella 2 (P2) 等特定的特征与由于微生物功能的改变而导致肥胖,高血压和糖尿病的风险增加有关.
科学领域:
- 微生物组研究的研究.
- 代谢健康 代谢健康
- 人类生理学 人类生理学
背景情况:
- 肠道微生物群对人类健康至关重要,影响新陈代谢和免疫力.
- 肠道微生物群落的破坏越来越多地与代谢障碍有关.
- 肠型聚类是一种用于分类肠道微生物组合的方法.
研究的目的:
- 调查大规模日本队列中肠道微生物组概况和代谢健康之间的关联.
- 为了确定与代谢疾病风险相关的特定肠道微生物肠型.
- 探索不同肠型对宿主新陈代谢的功能影响.
主要方法:
- 16S rRNA基因测序被用来分析肠道微生物组合.
- 应用了四种肠型和精细的七种肠型聚类来分类微生物特征.
- 进行了微生物代谢影响网络分析,以了解功能相互作用.
主要成果:
- 细菌体2 (B2) 肠型与较低的α多样性和肥胖和高血压风险增加有关.
- 发现了一种新的Prevotella 2 (P2) 肠型,与肥胖和糖尿病风险增加近两倍有关.
- B2和P2肠型显示,短链脂肪酸 (SCFA) 生产者的数量减少,机会性病原体的丰富.
- 观察到肠型特异的微生物相互作用模式,影响代谢物产生.
结论:
- 精细的肠型聚类有效地揭示了与代谢风险相关的独特的肠道微生物模式.
- B2和P2肠型代表了代谢性疾病的高风险微生物特征.
- 这些发现支持基于微生物组的分层和早期干预策略,用于代谢性疾病管理.
相关概念视频
Bacterial Phylum Bacteroidota
131
The phylum Bacteroidota includes over 700 species classified into four primary orders: Bacteroidales, Cytophagales, Flavobacteriales, and Sphingobacteriales. These gram-negative, non-sporulating rods exhibit saccharolytic capabilities and can be aerobic or fermentative, encompassing obligate aerobes, facultative aerobes, and obligate anaerobes. Many species display gliding motility, though some are nonmotile or use flagella. The genus Bacteroides is well-studied due to its significant role in...
131
Bacterial Phylum Proteobacteria
152
Proteobacteria, one of the largest and most diverse bacterial phyla, encompasses a wide range of Gram-negative bacteria distinguished by their outer membrane composed of lipopolysaccharides. These microorganisms exhibit various metabolic capabilities, including phototrophy, chemolithotrophy, and heterotrophy, and thrive in diverse environments from soil to aquatic systems and host-associated niches. The phylum is divided into six classes: Alphaproteobacteria, Betaproteobacteria,...
152
Factors Affecting the Risk of Infection
12.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.3K
Bacterial Phylum Tenericutes
94
The phylum Tenericutes, which includes the single class Mollicutes, comprises bacteria that lack cell walls. The term "Mollicutes" derives from the Latin word mollis, meaning "soft." These organisms are among the smallest known and are commonly referred to as mycoplasmas due to the prominence of the genus Mycoplasma, which includes well-known human pathogens. Despite their inability to stain gram-positively (a result of their lack of cell walls), mycoplasmas are phylogenetically related to the...
94
Bacterial Flora of the Large Intestine
651
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
651
Bacterial Phylum Firmicutes
156
Firmicutes is a diverse phylum of Gram-positive bacteria characterized by a low GC content in their genomes. This phylum includes organisms with monoderm or diderm cell envelopes, highlighting a complex evolutionary history. Firmicutes comprises several major orders, including Lactobacillales, Clostridiales, and Bacillales, which exhibit remarkable diversity in their morphology, metabolism, and ecological roles.The order Lactobacillales includes lactic acid bacteria, which are fermentative...
156


