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在MetALD中,持续的暴饮暴饮史与晚期肝纤维化和全因死亡率有关
Zhe-Kun Xiong1, Ru-Tao Lin2, Bi-Wei Chen1
1Department of Spleen, Stomach and Hepatobiliary, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan, China.
Alimentary pharmacology & therapeutics
|July 21, 2025
概括
持续的暴饮暴饮 (PBD) 病史显著增加了晚期肝纤维化和所有原因死亡的风险,这些人有代谢功能障碍和与酒精有关的肝病 (MetALD). 对饮酒模式的临床评估对于评估MetALD预后至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 与酒精有关的疾病与酒精有关的疾病
背景情况:
- 代谢功能障碍和与酒精有关的肝病 (MetALD) 影响中度饮酒和同时存在的代谢问题的人.
- 特定饮酒模式,如持续狂饮 (PBD),对MetALD严重程度和结果的影响尚不清楚.
研究的目的:
- 为了调查PBD病史与晚期肝纤维化的风险和被诊断为MetALD.的个体的全因死亡率之间的关联.
主要方法:
- 对成年患有MetALD.的NHANES数据 (1999-2016) 的分析.
- 经常大量饮酒 (≥4名女性,≥5名男性) 定义的PBD.
- 使用FIB-4指数评估的高级纤维化;来自国家死亡指数的死亡率数据;使用多变量回归模型.
主要成果:
- 37.7%的MetALD患者有PBD的病史.
- 病史与明显更高的晚期纤维化风险有关 (aOR=2.23).
- PBD与全因死亡率 (aHR=1.48) 和住院风险 (aOR=1.88) 的增加有关.
结论:
- 持续暴饮暴饮的病史是MetALD中晚期纤维化和死亡率的重要危险因素.
- 对MetALD的临床评估应包括对饮酒模式的详细评估,特别是PBD.
- 了解饮酒史对于改善MetALD患者的预后至关重要.
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