相关实验视频
Updated: Sep 14, 2025

07:37
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
370
高的类风湿因子不会降低TNF抑制剂在血清阳性JIA中的有效性
Boris Hügle1, Gerd Horneff2, Johannes-Peter Haas3
1Rheumatology Center Rhineland Palatinate, Hospital for Pediatric Rheumatology, Kaiser-Wilhelmstrasse 9-11, 55543, Bad Kreuznach, Germany. boris.huegle@rheumazentrum-rlp.de.
Pediatric rheumatology online journal
|July 21, 2025
概括
在患有类风湿因子阳性多关节炎的儿科患者中,瘤缩因子抑制剂 (TNFi) 无论类风湿因子 (RF) 水平如何,都表现出类似的疗效. 这与成人研究形成鲜明对比,表明射频对儿童的TNFi有效性没有影响.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 风湿性因子 (RF) 可以与免疫球蛋白的Fc部分结合,可能会影响含Fc的TNF抑制剂 (TNFi) 的疗效.
- 以前对患有类风湿性关节炎 (RA) 的成年人进行的研究表明,射频可能会影响TNFi的疗效,但这尚未在儿童群体中确立.
- 了解RF在儿科血清阳性多关节炎中的作用对于优化治疗策略至关重要.
研究的目的:
- 在被诊断为血清阳性多关节炎的儿童中研究TNF抑制剂 (TNFi) 的疗效.
- 为了确定不同的类风湿因子 (RF) 水平是否会影响儿科患者TNFi治疗的有效性.
- 为了比较TNFi在儿童高高射频与低射频的疗效.
主要方法:
- 通过对两个数据库的追溯搜索,确定了2009年11月至2023年3月期间接受治疗的患有青少年异常性关节炎 (JIA) /血清阳性多关节炎的儿科患者.
- 数据包括人口统计,抗风湿药物和青少年关节炎疾病活动评分 (JADAS27) 以及其核心组件版本 (cJADAS27) 在TNFi启动前后.
- 用重复测量ANOVA和ANCOVA来比较RF<160U/ml和RF≥160U/ml的患者之间的JADAS27和cJADAS27得分的变化.
主要成果:
- 包括28名儿科患者:有16名RF<160U/ml,12名RF≥160U/ml.
- 大多数患者接受了乙太 (75%) 和甲铁 (82%).
- 平均JADAS27 (cJADAS27) 评分从基线 (23.0 ± 14.7 / 21.0 ± 12.1) 到治疗后 (4.8 ± 5.0 / 4.8 ± 4.7) 显著改善,RF组之间的改善没有显著差异.
结论:
- 在这种患有血清阳性多关节炎的儿科患者队列中,高的类风湿因子水平并没有降低TNF抑制剂的疗效.
- 这些发现与成年人群的观察结果形成鲜明对比,表明RF和TNFi在儿童中的有效性之间存在不同的关系.
- 需要进一步的研究来验证这些结果并阐明底层机制.
相关概念视频
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
236
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
236
T Cell Types and Functions
1.4K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.4K
The JAK-STAT Signaling Pathway
9.3K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
9.3K
Rheumatic Heart Disease III: Medical Management
33
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
33
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
65
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
65
Rheumatic Heart Disease I: Introduction
46
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
46

