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相关实验视频

Updated: Sep 14, 2025

Genetic Manipulation of the Mouse Developing Hypothalamus through In utero Electroporation

Genetic Manipulation of the Mouse Developing Hypothalamus through In utero Electroporation

Published on: July 24, 2013

在雌性大鼠下丘脑发育的转录组分析.

Emily N Hilz¹, Madeline Streifer¹, Tyler M Milewski¹

¹Division of Pharmacology & Toxicology, The University of Texas at Austin, Austin, TX, 78712, USA; Center for Molecular Carcinogenesis & Toxicology, The University of Texas at Austin, Austin, TX, 78712, USA.

Molecular and cellular endocrinology

|July 22, 2025

概括

此摘要是机器生成的。

雌性大鼠的下丘脑发育显示,从婴儿期到青春期,在弧形核 (ARC) 和前侧周周核 (AVPV) 中,基因表达有显著的变化,FSH与基因活性有很强的相关性.

关键词:

脑前中心周周结核 (AVPV)弧形核 (ARC) 是指一个弧形核.能源平衡能源平衡能源平衡下丘脑的下丘脑是什么意思生殖生殖生殖生殖繁殖文字转录学 (Transcriptomics) 是一个学科.

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Published on: November 14, 2018

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Last Updated: Sep 14, 2025

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科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
内分泌学在内分泌学.

背景情况:

脑下垂体弧形核 (ARC) 和前脑周周核 (AVPV) 对于调节生殖,能量平衡,压力和神经调节至关重要.
这些区域在神经和质群体中经历了显著的发育变化,这对成人功能至关重要.

研究的目的:

在雌性大鼠的ARC和AVPV中,全面比较关键发育阶段 (婴儿,近青春期,成年) 的无偏转录特征.
识别发育性基因表达模式及其与生理激素变化之间的相关性.

主要方法:

利用3'向RNA测序,在8,30和60日出生后的ARC和AVPV中分析基因表达.
进行无偏见和先验差异性基因表达分析,重点关注与繁殖,新陈代谢,压力和神经调节相关的基因.
测量血清激素水平作为一个生理相关的.

主要成果:

在ARC和AVPV的婴儿和青春期前阶段之间观察到强大的差异基因表达,具有相当大的转录重叠.
在过渡到成年期期间,发生的转录变化较少,更多的区域特异性变化.
基因本体学分析表明,在青春期之前有协调的发育编程,包括对发育过程的下调和对代谢/调节通路的上调.
在成年后,AVPV表现出持续的转录重塑,而ARC保持相对稳定.
毛囊刺激激素 (FSH) 与先验选择的下丘脑基因表达显示出最强的相关性.

结论:

脑下垂体发育涉及显著的转录转移,特别是在青春期之前,在ARC和AVPV中具有明显的成人重塑模式.
这些发现为了解雌性大鼠整个生命阶段的下丘脑发育和激素基因相互作用提供了宝贵的参考.