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Updated: Sep 14, 2025

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
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Published on: July 3, 2020

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作为SERPINF1突变诱导的VI型骨质变异不完美的潜在治疗点,内质网膜应激和自

Yang Tian1, Xinyu Chen1, Shuoshuo Wei2

  • 1Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China; Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong 250021, China; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, Shandong 250021, China; "Chuangxin China" Innovation Base of stem cell and Gene Therapy for endocrine Metabolic diseases, China; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, Shandong 250021, China; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, Shandong 250021, China.

Life sciences
|July 22, 2025
PubMed
概括

新型SERPINF1突变通过破坏色素表皮衍生因子 (PEDF) 分泌,导致骨质细胞中ER压力和亡,导致VI型骨质生殖不完美. 细胞激活ERAD和自,以应对积累的突变蛋白质.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.自自是一种自的过程.细胞内膜网膜应激压力骨质发生不完美症 (osteogenesis imperfecta) 是一个不完美的疾病.在PEDF中,PEDF是PEDF.在SERPINF1中使用.

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