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Updated: Sep 14, 2025

In Vivo Modeling of the Morbid Human Genome using Danio rerio
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In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

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艾维维:一种新的人工智能框架,用于对毒基因组学数据进行增强的In Vitro到In Vivo推断 (IVIVE)

Mansi Chandra1,2, Ting Li1, Weida Tong1

  • 1National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, 72079, USA.

Toxicological sciences : an official journal of the Society of Toxicology
|July 22, 2025
PubMed
概括

人工智能辅助IVIVE (AIVIVE) 增强了毒基因组学数据外推,从体外数据中生成体外类似的基因表达特征. 这种新的框架改善了毒性预测,并支持药物安全中的3R原则.

关键词:
在体外-体内活体抽取 (IVIVE)生成性AI是一种人工智能.生成性的对抗性网络 (GANs)当地优化 地方优化有毒基因组学 (TGx)

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Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms08:46

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In-vitro Mutagenesis

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Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
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Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
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Methods for Studying Drug Absorption: In vitro

In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
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