向eRNA产生超级增强剂调节TNFα表达并缓解老鼠和患者衍生的免疫细胞中的慢性炎症

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Updated: Sep 14, 2025

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Minjeong Cho1, Su Min Kim1, Jiyeon Lee1

  • 1Department of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|July 22, 2025
PubMed
概括

向增强型RNAs (eRNAs) 提供了一种新的方法,通过减少瘤亡因子α (TNFα) 生产来对抗慢性炎症. 这项研究表明,eRNA抑制在临床前模型中有效缓解炎症疾病症状.

关键词:
这是一种反意义的寡核酸.慢性炎症是一种慢性炎症.增强RNA的RNA增强剂可以增强RNA.类风湿性关节炎 类风湿性关节炎瘤丧亡因子α因子

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