产科并发症,皮质变,以及第一期精神病的认知
Ana Costas-Carrera1,2, Norma Verdolini3, Gisela Mezquida4,5,6,7
1Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain.
产科并发症会影响患有第一期精神病症 (FEP) 的男性的大脑转化. 这些并发症会影响工作记忆,而化可能会在健康个体中调解这种关系,而不是FEP患者.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发育神经科学的发展神经科学.
背景情况:
- 产科并发症 (OCs) 与精神分裂症的认知和大脑异常有关.
- 皮层完整性的衡量标准 - - 陀螺变化 - - 在第一发精神病 (FEP) 中发生变化.
研究的目的:
- 为了研究OCs和FEP中的化之间的关系.
- 为了确定化是否介导了OCs和认知功能之间的联系.
主要方法:
- 在FEP患者和健康对照组 (HCs) 中比较局部化指数 (LGI).
- 在LGI上使用了OC和诊断相互作用的回归分析.
- 对LGI对OC和认知的影响进行调解分析.
主要成果:
- 与HCs相比,FEP患者在表皮,带皮和皮皮层中显示出显著的LGI差异.
- 在男性中发现了OCs和左带皮层 (LCC) LGI诊断之间的显著相互作用,由妊娠OCs驱动.
- OCs直接影响HC患者的工作记忆,但不影响FEP患者.
结论:
- OCs与诊断相互作用,以预测LCC化,男性患有FEP和OCs表现出最低的LGI.
- OCs影响工作记忆,而LCC转化可能会在HC中调解这一点,这表明精神病中存在不同的神经发育途径.
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