随机对照试验:营养补充剂通过向肠道微生物群来缓解易怒肠综合征症状
Maartje van den Belt1, Zhuang Liu2, Lonneke Janssen Duijghuijsen1
1Wageningen Food & Biobased Research, Wageningen University & Research, Wageningen, The Netherlands.
Journal of nutritional science
|July 22, 2025
概括
四种营养补充剂没有增加刺激性肠综合征 (IBS) 患者的有益肠道细菌 (Bifidobacterium). 与安慰剂相比,没有观察到症状或生活质量的显著改善.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究的研究.
- 营养科学 营养科学
背景情况:
- 刺激性肠综合征 (IBS) 管理通常涉及饮食变化,冒着营养缺乏的风险.
- 营养补充剂正在通过微生物组调节来探索IBS症状缓解,但证据有限.
- 某些特定的补充剂,如耐药粉,豆纤维,丁硫酸盐和蛋白质水解剂,缺乏针对IBS的强有力的科学验证.
研究的目的:
- 评估四种营养补充剂的双胞胎产生的潜力.
- 评估它们对IBS症状,肠道微生物群,短链脂肪酸 (SCFA),便模式和生活质量 (QoL) 的影响.
- 在随机对照试验中,将这些效应与安慰剂进行比较.
主要方法:
- 一项为期4周的随机,双盲,安慰剂对照研究,涉及70名IBS患者 (ROME IV标准).
- 干预组每天接受耐药粉,豆纤维,氏素硫酸盐,蛋白质水解剂或安慰剂.
- 收集的数据包括每日症状/便报告,便样本,饮食摄入量,症状严重程度,生活质量和心理评估.
主要成果:
- 没有发现任何补充剂显著增加Bifidobacterium丰富度或便SCFA水平.
- 症状严重程度和QoL的群体内改善与安慰剂变化没有统计学上的差异.
- 这些干预措施没有在4周内在IBS患者中显示出显著的双生效应.
结论:
- 测试的营养补充剂未能在研究期间增加IBS患者的Bifidobacterium丰富度.
- 与安慰剂相比,没有观察到明显的症状或 QoL 改善.
- 未来的IBS研究应该包括运行期和更大的样本大小,以进行可靠的结果评估.
关键词:
体重指数 (BMI),人体质量指数.这种细菌是Bifidobacterium.欧洲药物管理局,生态瞬间评估罗斯福,虚假发现率FFQ,食物频率调查问卷功能性食品是一种功能性食品.HADS,医院焦虑和抑郁症得分.刺激性肠综合症,刺激性肠综合症在IBS-C,IBS中占主导地位的是便秘.在IBS-D,IBS中主要出现腹.IBS-M,与便秘和腹混合的IBS.IBS-SSS,刺激性肠综合征严重性评分系统IBS-U,没有特定便模式的IBS.ITT,意图进行治疗.刺激性肠综合征是什么意思微生物群中的微生物群PCR,聚合酶连锁反应PP,每一个协议.质量,生活质量.简链脂肪酸 (SCFA) 是短链脂肪酸.严重程度的严重程度.更多相关视频
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