在2型糖尿病中,循环中的25-基维生素D与时间范围和胰岛素分泌的相关性
Wenwen Jiang1, Ling Li2, Wei Wang3
1Department of Endocrinology, Jinling Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Frontiers in endocrinology
|July 22, 2025
概括
在2型糖尿病患者中,较高的维生素D水平与更好的葡萄糖控制和胰岛素分泌相关. 低25-基维生素D水平可能会对葡萄糖平衡和胰腺β细胞功能产生负面影响.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 营养科学 营养科学
背景情况:
- 2型糖尿病 (T2DM) 是一个全球性的健康问题.
- 维生素D缺乏症在T2DM患者中很常见.
- 在T2DM血糖控制和胰岛素分泌中25-氧维生素D[25(OH) D的作用需要进一步研究.
研究的目的:
- 研究血清25-基维生素D [25(OH) D]水平与血糖控制参数之间的关联,包括T2DM患者的时间范围 (TIR) 和胰岛素分泌.
主要方法:
- 包括911名T2DM患者,测量血清25(OH) D和为期3天的连续血糖监测 (CGM).
- 根据25...OH) D水平,患者被分为三分之一.
- 评估了血糖变化 (GV),HOMA-IR,HOMA-β和胰腺β细胞分泌功能 (通过一个子集的饮食测试).
主要成果:
- 较高的25...OH) D水平与增加的TIR和在狭窄范围内 (TITR) 的时间显著相关.
- 血清25(OH) D显示了与时间超出范围,GV参数,HbA1c和HOMA-IR的负相关性.
- 血清25(OH) D与早期阶段和胰腺总体β细胞分泌能力的指标具有正相关性.
结论:
- 在T2DM患者中,循环中的25(OH) D水平与TIR和葡萄糖刺激的胰岛素分泌积极相关.
- 较低的25(OH) D水平可能会导致T2DM中葡萄糖平衡和胰腺β细胞功能受损.
- 保持足够的维生素D状态可能有利于管理T2DM.
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