基于 fondaparinux 的 PROTAC 药物分子的设计,合成和抗炎作用

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Ruoxuan Wu1,2,3,4, Tianji Zhang5,6, Siran Zhao5,6

  • 1State Key Laboratory of Green Biomanufacturing, Beijing University of Chemical Technology, Beijing, China.

Frontiers in bioengineering and biotechnology
|July 22, 2025
PubMed
概括

这项研究通过将Fondaparinux Sodium与药物结合,开发了新的蛋白质分解向仿真体 (PROTACs). 优化生产产生了高纯度的PROTACs,可以抑制炎症介质,为向无法药物治疗的蛋白质提供了一种新的策略.

关键词:
这是一种抗炎药物.抑制细胞因子的抑制.芬达帕鲁努克斯 (FS) 是一种蛋白质溶解向的木乃伊 (PROTAC) 的研究.表面等离子体共振 (SPR) 是一种表面等离子体共振.

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