长期高脂肪饮食影响骨髓微环境在老化时单细胞分辨率
Yidan Pang1,2, Siyuan Zhu3, Peng Ding1,2
1Department of Orthopaedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China.
MedComm
|July 22, 2025
概括
在老年小鼠中长期高脂肪饮食 (HFD) 消费将骨髓从骨形成转移到脂肪生产. 这导致免疫细胞功能障碍和全身炎症,表明骨髓作为治疗点.
科学领域:
- 生物医学科学 生物医学科学
- 衰老研究研究 衰老研究
- 代谢性疾病 代谢性疾病
背景情况:
- 由于高脂肪饮食 (HFD) 而导致的肥胖和衰老是慢性疾病的重要风险因素.
- 了解长期HFD对衰老 (LHA) 的影响对于开发干预措施至关重要.
研究的目的:
- 研究LHA对骨髓微环境和固体器官的影响.
- 确定将LHA与病理和炎症联系起来的分子机制.
主要方法:
- 建立一个长期的HFD到老化 (LHA) 的小鼠模型.
- 骨髓细胞的单细胞转录组学分析.
- 对基因表达的分析,包括巨细胞中的Chil3和Fabp4.
主要成果:
- 在骨髓中,LHA诱导骨质生成转变为脂肪生成.
- LHA改变了免疫细胞群和它们的代谢适应.
- 在骨髓巨细胞中观察到Chil3和Fabp4的上调.
- 确定了骨髓和大脑之间的潜在交叉轴 (Ptn-Sdc3,Cxcl12-Cxcr4).
结论:
- 骨髓微环境是LHA诱导病理的中心枢纽.
- 脂肪性重编程和髓状细胞功能障碍驱动LHA中的炎症.
- 准骨髓为肥胖加速衰老提供了治疗潜力.
更多相关视频
05:27Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing
Published on: January 26, 2024
1.3K
07:45Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis
Published on: November 28, 2015
35.8K
相关概念视频
01:29Bone Disorders
4.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.0K
01:19The Effect of Aging on Tissues
2.5K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.5K