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2009年至2018年期间法国骨转移的流行病学
Clarisse Marchal1, Manon Belhassen1, Gaëlle Désaméricq2
1Pharmaco-Epidémiologie Lyon (PELyon), Lyon F-69007, France.
JBMR plus
|July 22, 2025
概括
骨转移 (BM) 的发病率在法国正在上升,乳腺癌,前列腺癌和肺癌是最常见的原发病地. 与骨相关的事件 (SREs) 是频繁的,需要紧急的管理策略.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 骨转移 (BM) 是癌症的常见并发症,导致显著的骨相关事件 (SREs).
- 最近的流行病学数据缺乏法国发生的BM患者.
- 了解BM流行病学对于开发有效的患者护理策略至关重要.
研究的目的:
- 描述2009年至2018年期间在法国发生的骨转移 (BM) 的流行病学.
- 分析BM发病率的趋势,并确定原发性癌症类型.
- 评估与骨相关事件 (SREs) 的发生及其管理.
主要方法:
- 使用了法国医疗保险退款数据库 (受益人的总样本).
- 使用住院代码或SRE代码 (病理性骨折,脊柱压缩,高热血症,严重骨疼痛) 识别新的成人BM患者.
- 排除了在纳入前3年内患有原发性肉瘤或流行性骨髓瘤的患者.
主要成果:
- 在10年内确定了6,663名新的BM患者,代表了法国的775,973人.
- 观察到BM的原始发病率显著增加,从2009年至2018年平均年增长8.6%.
- 乳腺癌 (15.8%),前列腺癌 (13.4%) 和肺癌 (12.6%) 是最常见的原发性癌症. 4,737名患者经历了SRE,其中66.4%接受了阿片类药物和39.6%接受了NSAID.
结论:
- 骨转移代表了法国日益严重的公共卫生问题,发病率显著上升.
- 与骨相关事件的高负担强调了需要改进管理和有针对性的干预措施.
- 需要紧急制定具体策略,以应对骨转移和SRE对患者护理的重大影响.
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