不活跃的肺结核病变与老年人活跃疾病发展风险的关联:基于人口的回顾性研究
Lingyu Shen1,2,3, Yu Zhang4,3, Henan Xin1,2,3
1NHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
ERJ open research
|July 22, 2025
概括
患有非活性肺结核 (PTB) 病变的个人面临着明显更高的患有活性PTB的风险. 早期干预策略对于这些高风险人群的结核病控制至关重要.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 传染性疾病 传染性疾病
背景情况:
- 不活跃肺结核 (PTB) 病变与患有活跃PTB的风险增加有关.
- 识别高风险人群对于有针对性的干预策略至关重要.
- 之前的研究强调,需要针对特定类型的病变提供流行病学证据.
研究的目的:
- 评估不同类型的不活跃PTB病变与活跃PTB病变的发展之间的关联.
- 为结核病控制中准确的干预策略提供流行病学证据.
- 评估不活跃的病变和先前的抗结核病治疗对活跃的PTB风险的综合影响.
主要方法:
- 基于人口的PTB活跃案例寻找项目的回顾性分析.
- 包括2020年基线调查中的154,028名老年受试者.
- 2年的随访,以确定微生物学确认的活跃PTB事件.
主要成果:
- 活跃PTB的整体发病率为每100人/年0.19.
- 不活跃的PTB病变 (纤维化,化,胸腔加厚,结节) 独立地与增加活跃的PTB风险相关 (aHR为2.94-6.55).
- 单独的非活性病变 (aHR 6.96) 和单独的抗结核病治疗史 (aHR 7.67) 增加了风险;综合效应显示aHR 10.50.
结论:
- 患有不活跃PTB病变的个体,无论类型或治疗史,都面临活跃PTB的风险较高.
- 这些发现强调了对非活跃PTB患者结核病控制的干预措施的重要性.
- 对于具有不活跃的PTB病变和有抗结核病治疗史的人来说,需要针对性的策略.
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