参考方程对三个非洲国家的螺旋测量解释的影响:一个横截面研究
Denise Banze1,2,3, Claire J Calderwood4,5,3, Celina Nhamuave2
1CIH Center for International Health, University Hospital, LMU Munich, Munich, Germany.
ERJ open research
|July 22, 2025
概括
全球肺功能倡议 (GLI) 全球方程可能高估了东部/南部非洲的肺功能障碍. 非洲的参考方程与GLI的非洲裔美国人相似,这表明需要区域特定的螺旋测量数据.
科学领域:
- 肺部医学 肺部医学
- 呼吸系统生理学 呼吸系统生理学
- 公共卫生 公共卫生
背景情况:
- 全球肺功能倡议 (GLI) 全球螺旋计参考方程缺乏来自非洲的代表性.
- 在东部/南部非洲,GLI Global尚未得到验证.
- 本研究评估了该地区的GLI和非洲参考方程.
研究的目的:
- 评估GLI和非洲螺旋计参考方程在东部/南部非洲的适应性和诊断影响.
- 用不同的参考方程来比较肺功能分类.
主要方法:
- 利用了来自莫桑比克,坦桑尼亚和津巴布韦的806名健康个体 (≥10岁) 的支气管扩展器后螺旋计数据.
- 在1秒内计算的强制呼吸量 (FEV1),强制生命能力 (FVC) 和FEV1/FVC z-score.
- 在不同的方程中比较了阻塞性呼吸道疾病和维护比率受损的螺旋计的比例.
主要成果:
- 在GLI方程中,GLI"非洲裔美国人"方程提供了最合适的方程.
- 与"非洲裔美国人"方程相比,GLI Global发现的维护比率受损的螺旋测量个体是"非洲裔美国人"方程的两倍 (22%对11%).
- 阻塞的比例在"非洲裔美国人"和GLI全球方程 (4.2%对3.8%) 中是相似的. 非洲开发的方程显示与GLI"非洲裔美国人"相似.
结论:
- 参考方程对临床和公共卫生评估产生重大影响,特别是在资源有限的环境中.
- 在这个人群中,GLI Global可能会导致肺功能障碍的过度诊断.
- 需要进一步研究包括临床结果,以确保GLI全球的全球代表性.
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