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人类癌症中dbc1表达的预后和临床病理学价值:系统性审查和元分析

Haojia Wang^{1,2,3,4,5,6,7,8}, Xinhong Cheng^1,9,10, Bruce Xianzhuo Zhang¹¹

¹The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.

Frontiers in oncology

|July 22, 2025

概括

癌症患者的高DBC1蛋白水平与较差的整体存活率和无复发存活率相关. 提升的DBC1表达也与晚期TNM阶段,远程转移和更高的组织学等级有关,表明其作为预后标记物的潜力.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物研究生物标志物研究

背景情况:

DBC1 (Deleted in Breast Cancer 1) 是一种涉及人类癌症发展的核蛋白.
在癌症患者中DBC1的预后和病理意义仍然存在争议.
这一元分析旨在澄清DBC1在癌症预后和病理学中的作用.

研究的目的:

调查DBC1表达和患者存活率 (总体存活率和无复发存活率) 之间的关联.
探索DBC1表达与癌症患者各种病理特征的相关性.
评估DBC1作为癌症潜在的预测性预后标志物.

主要方法:

在PubMed,Web of Science,Embase,CNKI和Wanfang数据库中进行了系统的文献搜索.
来自25项涉及4014名癌症患者的研究的数据被纳入了元分析.
使用STATA 14.0.0计算了95%置信区间 (CI) 的危险比率 (HR) 和比率比率 (RR).

主要成果:

DBC1过度表达与较短的整体存活率 (HR = 1.948,P = 0.002) 和无复发的存活率 (HR = 2.182,P = 0.000) 显著相关.
较高的DBC1表达与较差的TNM阶段 (RR = 1.245,P = 0.038),远程转移 (RR = 1.987,P = 0.043) 和较高的组织学等级 (RR = 1.433,P = 0.005) 相相关.
在生存和病理结果的研究中观察到很高的异质性 (I2 > 60%).

结论:

DBC1过度表达是癌症患者预后不佳和不良病理特征的重要指标.
DBC1有可能成为癌症的预测性预后生物标志物.
需要进一步进行高质量的前性研究来验证这些发现.

关键词:

DBC1 DBC1 是一个这种癌症是癌症癌症.临床病理学特征临床病理学特征进行元分析分析.预后预后预后

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