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患有支气管肺功能失调的非常早产婴儿生命早期肠道微生物群的变化:一项嵌套病例对照研究
Tao Ning1,2, Xiaoxue Shan1, Xiaowen Zhuang1
1Department of Pediatrics, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Frontiers in microbiology
|July 22, 2025
概括
患有支气管肺功能失调 (BPD) 的非常早产婴儿表现出肠道微生物群失调. 增加Ureaplasma urealyticum的丰富性和减少Veillonella dispar可能会增加BPD风险.
科学领域:
- 新生儿医学 新生儿医学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 支气管肺功能障碍症 (BPD) 是非常早产婴儿的一种严重并发症.
- 了解肠道微生物组在BPD中的作用对于改善婴儿结果至关重要.
研究的目的:
- 为了调查诊断为BPD的非常早产婴儿的肠道微生物群的变化.
- 分析肠道细菌和短链脂肪酸 (SCFA) 在BPD发展中的关系.
主要方法:
- 50名非常早产婴儿 (妊娠年龄24+031+6周) 被招募并分为BPD和对照组.
- 在第1,7,14,21和28天收集了便样本,用于16S rDNA细菌分析和SCFA量化.
- 30名婴儿在排除后完成了这项研究.
主要成果:
- 在第一天,与对照组相比,BPD组具有较高的Ureaplasma urealyticum (UU) 和较低的Bacteroidota丰度.
- 微生物群差异在第7天和第14天减少,在第14天没有观察到SCFA差异.
- 在BPD群体中,在28日之前,Veillonella dispar的显著下降被发现,这表明逐渐下降.
结论:
- 患有BPD的非常早产婴儿表现出肠道微生物群失调.
- 1日升高的UU和28日降低的Veillonella dispar是BPD的潜在危险因素.
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