人类牛奶细菌体和真菌体以及它们在地理位置上的互动
Haipeng Sun1, Brett Finlay2,3, Meghan B Azad3,4
1Department of Biochemistry & Microbiology, Rutgers University, New Brunswick, NJ, United States.
Frontiers in nutrition
|July 22, 2025
概括
全球变异显著影响人乳微生物群,包括细菌,古生物和真菌. 了解这些多样化的微生物群落对于母亲和婴儿的健康至关重要.
科学领域:
- 微生物学 微生物学
- 人类微生物组研究研究
- 全球卫生研究全球卫生研究
背景情况:
- 人母乳微生物群在婴儿健康中起着至关重要的作用,但影响它的因素仍然不太清楚.
- 之前的研究受限于小样本大小和单个地理位置,主要关注细菌.
- 这项研究解决了对母乳微生物组进行全面,全球评估的需求.
研究的目的:
- 在全球多样化的人口中研究母乳的细菌,古物和真菌组成.
- 探索人乳微生物组内的潜在的跨王国相互作用.
- 为了确定牛奶微生物群落的地理差异.
主要方法:
- 分析了来自16个国家的518个母乳样本,使用16S rDNA和ITS2细菌和真菌的基因测序.
- 采用定量PCR (qPCR) 检测甲原始物.
- 利用共同丰富性网络分析来研究微生物相互作用.
主要成果:
- 在牛奶细菌多样性和分类中观察到显著的国家特异性差异.
- 核心细菌属如 *Staphylococcus*, *Streptococcus* 和 *Bifidobacterium* 在全球普遍存在,但其丰富度各不相同.
- 菌存在 (*Candida*) 和考古检测 (*Methanobrevibacter*) 显示出地理差异,网络分析揭示了复杂的王国间相互作用.
结论:
- 在人类牛奶微生物群中存在大量的全球变异,包括细菌,古生物和真菌.
- 牛奶中的细菌-真菌相互作用是显著的.
- 大规模的全球性研究对于了解人乳微生物组在母婴健康中的作用至关重要.
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