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营养不良介导着手握状况和喘风险之间的关联:来自多个欧洲国家的观察和前性队列研究

Jun Wen¹, Xiaowen Shi¹, Yan Liu¹

¹Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.

Frontiers in nutrition

|July 22, 2025

概括

下手握强度 (HGS) 和相对手握强度 (RHGS) 与欧洲成年人喘风险增加有关. 营养不良部分调解了这种联系,这表明改善肌肉力量是潜在的喘预防策略.

科学领域:

流行病学流行病学
公共卫生公共卫生
老年学是一门学科.

背景情况:

关于手握状态和喘风险之间的联系的流行病学研究有限.
与喘风险相关的手握强度 (HGS),相对手握强度 (RHGS) 和低HGS的调查至关重要.
要了解营养状况在这种关联中的调解作用,需要进一步探索.

研究的目的:

通过使用欧洲人口数据,研究手握强度与喘风险之间的关联.
为了评估手握状态对喘风险的预测性能.
为了确定营养状况是否介导着握力和喘之间的关系.

主要方法:

利用来自欧洲健康,老龄化和退休调查 (SHARE) 的横截面和前性队列数据.
使用机器学习模型 (XGBoost,SHAP),逻辑回归和Cox回归来分析手握状态和喘风险.
应用调解效果模型来评估营养状况的作用.

主要成果:

在横截面和前性分析中,HGS和RHGS与喘风险相反相关.
低HGS被确定为喘的危险因素.
机器学习模型,特别是XGBoost,表现出强大的预测性能,其中RHGS,HGS,国家,年龄和慢性肺病是关键预测因素. 营养不良部分调解了低HGS-喘风险关系 (2.71%).

结论:

较低的手握强度和RHGS与欧洲人口中喘风险更高有关.
手握状态可以作为喘风险的独立标志物.
提高肌肉力量可能为喘提供一个可行的预防策略,具有重大公共卫生影响.

关键词:

沙普利的添加式解释 (SHAP)喘喘是一种手握强度 (HGS) 是指手握的强度.机器学习是机器学习.营养不良营养不良营养不良相对握手强度 (RHGS) 是指相对握手强度.

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