全球结直肠癌的潜在减少,1990-2021年
Zilin Luo1,2, Xuesi Dong1,2, Le Wang3
1Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Journal of the National Cancer Center
|July 22, 2025
概括
可预防的生活方式因素对结直肠癌负担有显著的贡献. 全球消除这些风险可以使男性和女性的预期寿命增加0.1年以上.
科学领域:
- 全球健康 全球健康
- 癌症流行病学 癌症流行病学
- 预防医学 预防医学
背景情况:
- 结肠直肠癌 (CRC) 是一个重大的全球健康挑战.
- 针对可修改风险因素的初级预防策略对于降低CRC负担至关重要.
- 关于生活方式因素对CRC的影响和潜在的预期寿命增长的定量数据仍然不确定.
研究的目的:
- 评估因可改变的生活方式因素而导致的结直肠癌的全球负担.
- 量化消除这些风险因素所导致的预期寿命的潜在增加.
主要方法:
- 利用了2021年全球疾病负担研究的数据.
- 检查了可修改的风险因素 (吸烟,饮食等) 所导致的CRC死亡和残疾调整寿命年 (DALYs). 从1990年到2021年,在全球,区域和国家层面进行了研究.
- 采用缩短周期寿命表方法来估计潜在的预期寿命增长.
主要成果:
- 2021年,57.1%的CRC死亡和56.4%的DALY是可以预防的.
- 可修改的CRC负担在较高的社会人口指数五分位数下降,但在低中五分位数上升.
- 在2021年消除可修改因素可以使全球预期寿命大约增加0.107年男性和0.109年女性.
结论:
- 可修改的生活方式因素代表着相当大的,可预防的结直肠癌负担.
- 通过消除这些风险因素,可以实现预期寿命的显著增长.
- 专注于生活方式修改的公共卫生干预措施对于预防CRC至关重要.
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