多发性骨髓瘤:阿曼的临床表现和结果的真实数据
Ibrahim Al Nabhani1, Jaber Al Lawati2, Nooh Al Mahrooqi3
1Department of Hematology Sultan Qaboos University Hospital Muscat Oman.
EJHaem
|July 22, 2025
概括
这项研究分析了阿曼的多发性骨髓瘤 (MM),发现了晚期疾病的年轻患者. 国际分期系统阶段预测了整体存活率,但由于数据限制,治疗效果仍然不清楚.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床研究 临床研究
背景情况:
- 关于阿曼和周边地区的多发性骨髓瘤 (MM) 的数据有限.
- 了解阿曼MM患者的临床表现和生存结果对于区域医疗保健规划至关重要.
研究的目的:
- 报告在苏丹卡布斯大学医院 (SQUH) 接受治疗的多发性骨髓瘤患者的临床特征和生存结果.
- 为未来的比较研究提供阿曼MM的基线数据.
主要方法:
- 在2008年6月至2018年12月期间在SQUH诊断和治疗的98名MM患者的回顾性分析.
- 数据收集包括来自电子医疗记录的人口统计,疾病特征和生存结果.
- 卡普兰-梅尔法和日志级别测试用于生存分析,按国际分级系统 (ISS) 阶段分层.
主要成果:
- 患者的平均年龄为61岁,比全球报告年龄更小. 大多数患者 (44%) 呈现出先进的ISSIII期疾病.
- 贫血 (50%),性病变 (41.5%) 和功能不全 (24.2%) 是常见的初始表现.
- 中位数无进展生存 (PFS) 为59个月,中位数整体生存 (OS) 为109个月. 国际空间站阶段有意义地预测了OS (p < 0.001),但没有PFS.
结论:
- 与国际队伍相比,阿曼MM患者往往更年轻,患有更晚期的疾病.
- 先进的ISS阶段是这一群体生存率较低的重要预测因素.
- 建议与更大的队列进行进一步的合作研究,以调查由于治疗变异和样本小而导致的治疗疗效.
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