在急性心肌梗塞患者中,PRECISE-DAPT癌症评分的外部验证
Mohamed Dafaalla1, Francesco Costa2,3, Evangelos Kontopantelis4
1Keele Cardiovascular Research Group, Centre for Prognosis Research, Keele University, Stoke-on-Trent, UK.
概括
PRECISE-DAPT癌症评分准确预测癌症急性冠状动脉综合征患者的出血风险. 这种经过验证的工具改进了原始得分,为这个特定的患者群体提供了更好的临床效用.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 临床风险预测预测
背景情况:
- 接受急性冠状动脉综合征 (ACS) 治疗的癌症患者面临高出血风险.
- 现有的风险评分可能无法充分捕捉癌症患者的出血风险.
研究的目的:
- 为外部验证PRECISE-DAPT癌症评分,用于预测癌症和ACS患者的出血事件.
- 将其准确性和临床有用性与原来的PRECISE-DAPT评分进行比较.
主要方法:
- 利用了来自BleeMACS注册表的数据,包括13,932名患者 (864名癌症患者).
- 使用C统计,净重新分类指数 (NRI) 和决策曲线分析,比较原始和癌症特异的PRECISE-DAPT得分.
主要成果:
- 癌症评分确定了更高比例的癌症患者患有高出血风险 (HBR) (94.9%与63.3%相比).
- 癌症评分显示出优异的歧视 (C统计值0.66对0.64) 和一个正的NRI (2.7%).
- 决策曲线分析表明,癌症得分在癌症患者中的优越性.
结论:
- PRECISE-DAPT癌症评分是用于预测癌症ACS患者出血风险的经过验证和临床有用的工具.
- 与这个群体的原始PRECISE-DAPT得分相比,它提供了更好的风险分层.
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