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优化获取用于肝脏中同步的intravoxel不连贯运动和R2量化

Gregory Simchick¹, Diego Hernando^1,2

¹Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Magnetic resonance in medicine

|July 22, 2025

概括

这项研究优化了MRI序列,以同时进行肝脏内素不连贯运动 (IVIM) 和R2量化. 优化的多回声序显示了IVIM和R2参数的良好重复性,这表明它在肝脏成像中的实用性.

科学领域:

磁共振成像 (MRI) 是一种磁共振成像技术.
生物物理学的生物物理.
医疗成像医学成像

背景情况:

内素不连贯运动 (IVIM) MRI 量化了微血管血流和扩散.
R2量化测量肝脏组织放松特性.
同时的IVIM和R2量化可以提供全面的肝脏组织特征.

研究的目的:

设计优化的b值,第一阶运动矩 (M1) 和回声时间 (TE) 获取参数,用于同时在肝脏中量化IVIM和R2.
为了评估测试-重复测试的可重复性和优化收购的内部协议.

主要方法:

使用Cramer-Rao下界优化开发了b-M1优化 (单个TE) 和b-M1-TE优化 (多TE) 的IVIM采集协议.
在11名健康志愿者中获取数据,并重复每个优化获取的数据进行测试-重新测试分析.
估计了IVIM参数 (D,f1,f2,Vb1,Vb2) 和R2参数 (R2t,R2b),并应用了六种R2校正方法.

主要成果:

对b-M1-TE优化的获取结果显示,对于右肝叶中的大多数IVIM和R2参数,可接受的可重复性很好.
对于D,Vb1,Vb2,R2t和R2b,观察到良好的内叶间协议,除了f1和f2之外.
在单个TE采购中使用固定的R2t和R2b值对f估计的R2校正给出了与多TE方法类似的结果.

结论:

优化了b-M1-TE的IVIM获取使得IVIM和R2在肝脏中的量化能够同时和可重复.
对于单个TE IVIM数据,使用固定R2t和R2b值为R2对f估计进行校正可能是可以接受的.

关键词:

在腹部,腹部,腹部.扩散加权成像技术的使用.在intravoxel不连贯的运动.肝脏肝脏肝脏肝脏肝脏肝脏定量的MRI是指MRI的数量.

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