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通过转录因子工程增强CAR-T细胞对抗固体瘤的功效

Ruoqi Chen1, Lianqing Chen2,3,4, Yu Tang2,3,4

  • 1Eye Center of Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases. Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, China.

JCI insight
|July 22, 2025
PubMed
概括

增强仿真抗原受体T (CAR-T) 细胞涉及修改转录因子 (TF). 了解TF网络是改善CAR-T疗法的关键,以获得更好的癌症治疗结果.

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Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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