类基因组中的内源性IHHNV元素的动态集成和进化轨迹
Xiaoyun Zhong1,2,3, Jianbo Yuan1,2,3, Xiaojun Zhang1,2,3
1Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture (KLBBSA), Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
概括
内源性病毒元素 (EVE) 作为分子化石,揭示了古代宿主病毒冲突. 这项研究在甲类动物中发现了许多由感染性皮下和造血性亡病毒衍生的感染性EVE (IHHNV-EVE),显示了正在进行的进化战斗.
科学领域:
- * 进化生物学 进化生物学
- * 基因组学 是一个学科.
- * 病毒学 病毒学
背景情况:
- *内源性病毒元素 (EVE) 是过去病毒感染的残留物,集成到宿主基因组中.
- *EVE提供了对病毒及其宿主之间的长期共同进化动态的见解.
- * 传染性皮下和造血性亡病毒 (IHHNV) 是甲类动物的重要病原体.
研究的目的:
- * 在甲类基因组中识别和描述IHHNV衍生的EVE.
- * 调查IHHNV-EVE的进化历史和分布.
- * 了解EVE在宿主病毒共同进化轨迹中的影响.
主要方法:
- *对105种甲动物基因组进行生物信息分析.
- * 基于序列同样性和基因组背景的IHHNV-EVE的识别和分类.
- *对古代和最近的EVE插入进行比较分析.
主要成果:
- *确定了252个IHHNV-EVE,包括183个古老的和6个最近的插入,分布在Decapoda,Thoracica和Isopoda.
- * 在Decapoda基因组中IHHNV-EVE的扩张表明进化军备竞赛加剧.
- *最近的IHHNV-EVE都是实验室污染物,其中一个真实集成在Penaeus monodon中.
结论:
- *EVE作为过去病毒冲突和正在进行的进化过程的双重档案.
- *病毒基因组殖民是一种连续性,古老的EVE固定和持久的整合同时发生.
- *这些发现为宿主病毒共同进化的途径提供了新的视角.
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