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在患有多发性硬化症的人中持续监测膀功能障碍:膀可穿戴设备
Valerie J Block1,2, Shane Poole1, Leah McIntyre2
1Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.
Annals of clinical and translational neurology
|July 22, 2025
概括
对于患有多发性硬化症 (MS) 的人来说,远程膀超声监测是可行的. 这项技术捕捉了真实世界的膀症状变化,改善了与MS相关的膀功能障碍的评估和护理.
科学领域:
- 神经学 神经学
- 生物医学工程 生物医学工程
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 超过85%的多发性硬化症患者 (PwMS) 经历了膀功能障碍.
- 目前的评估方法有限,无法捕捉现实世界的症状波动.
研究的目的:
- 评估一种新型远程膀超声波装置的可行性和有效性,用于在PwMS中在家监测膀功能障碍.
- 将远程测量与标准临床评估进行比较.
主要方法:
- 一项为期3个月的试点研究,涉及22名MS妇女,在家中使用可穿戴超声波设备.
- 与临床数据 (cPVR,3天膀日记) 进行远程空虚后残留 (rPVR) 和尿动频率 (rFrequency) 的比较.
- 使用布兰德-阿尔特曼分析和相关系数评估的协议.
主要成果:
- 很高的研究保留率 (86.4%) 和设备使用率 (14.1天).
- 远程和临床空白后残留测量之间的良好一致性.
- 远程和患者报告的尿动频率之间存在强烈的相关性 (ICC=0.81,r=0.793).
- 远程监测显示了显著的一天到一天的症状变化.
结论:
- 可穿戴式超声波技术是可行的,并且在PwMS中对膀功能障碍的远程监测具有初步有效性.
- 捕捉现实世界的症状变化可以改变评估和管理.
- 能够为MS患者提供更加个性化和响应性的护理策略.
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