免疫检查点抑制剂诱导的肺炎:系统性审查
Ana Casal1,2, Virginia Leiro1,2,3, Laura Villar1,2
1Pulmonary Department, Hospital Universitario Álvaro Cunqueiro, Vigo, Spain.
免疫检查点抑制剂 (ICI) 可以引起肺毒性,发生在1-7%的患者中. 本系统性审查详细介绍了ICI诱导肺炎的发病率,风险因素和结果,这对于早期检测和管理至关重要.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 越来越多地用于癌症治疗.
- 肺毒性是一种已知的,但变化的,ICI的不良影响.
- 关于ICI引起的肺损伤的流行病学和具体结果的数据有限.
研究的目的:
- 评估ICI诱导的肺损伤的频率,特征和结果.
- 综合目前关于ICI相关肺炎的证据.
- 确定这种不良事件的风险因素和进展模式.
主要方法:
- 进行了相关研究的系统审查.
- 包含和排除的标准是预先定义的.
- 在最终分析中包括了七项研究.
主要成果:
- ICI诱导的肺炎发病率在1%至7%之间.
- 抗PD-1药物显示的风险高于抗PD-L1药物.
- 具体的风险因素包括某些癌症类型,晚期,状组织学,高PD-L1表达和缺乏先前治疗.
结论:
- 与ICI相关的肺炎是一种严重的毒性,需要高度的临床怀疑.
- 本综述提供了ICI诱导的肺损伤的最新概况.
- 研究结果突出了未来研究的领域,以管理这种不良影响.
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