在COVID-19康复者中,具有与免疫球蛋白相关的持续性肺部症状的ACE-2类酶活性
Yufeng Song1, Frances Mehl1, Lyndsey M Muehling2
1Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA.
研究人员发现,一些从COVID-19 (冠状病毒疾病2019) 中恢复过来的个人会产生类似ACE2的酶类活性抗体. 这种类似ACE2的亚酶活性与长期COVID患者的血压问题相关.
科学领域:
- 免疫学和病毒学
- 心血管生理学心血管生理学
- 传染病的发病因子 传染病的发病因子
背景情况:
- COVID-19和长期COVID (LC) 呈现复杂的临床特征,包括血压不稳定,高炎症,凝血病和神经精神病症状,病因不明.
- 在SARS-CoV-2尖端蛋白的受体结合域 (RBD) 结合宿主细胞ACE2,启动感染.
- 之前的研究表明,在急性COVID-19患者中,免疫球蛋白相关的ACE2类蛋白解活性.
研究的目的:
- 调查COVID-19康复的个体是否存在ACE2类亚基酶.
- 确定康复期患者的ACE2类催化活性是否与临床表现相关,特别是血压调节.
- 探索一个潜在的机制,有助于长期COVID的病原体.
主要方法:
- 对从参加诊所治疗COVID-19后持续性肺部症状的个人所取的血清样本进行分析.
- 检测免疫球蛋白相关的ACE2类蛋白质分解活性 (酶).
- 在运动测试期间,ACE2类亚基酶的存在和血压变化之间的相关性分析.
主要成果:
- 在一组从COVID-19中康复的个人中发现了类似ACE2的亚酶.
- 在这些康复期患者中,ACE2类催化活性的存在与在运动测试期间观察到的血压变化相关.
- 这些发现扩展了从急性COVID-19到后急性阶段的先前观察.
结论:
- 从COVID-19中恢复过来的个体可以产生具有ACE2类酶性质的自身抗体.
- 这些类似ACE2的酶的存在与长期COVID的背景下血压失调有关.
- 这一发现为了解和治疗长期COVID的复杂症状提供了潜在的新途径.
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