单侧视神经炎和视网膜层在受影响和未受影响的眼睛中变薄
Sanna Leinonen1,2, Hanna-Mari Mäkelä1,2, Chi Li3
1Faculty of Medicine and Health Technology, University of Tampere, Tampere, Finland.
Acta ophthalmologica
|July 22, 2025
概括
多发性硬化症 (MS) 患有单侧视神经炎 (ON) 的患者在未受影响的眼睛中表现出内视网膜变薄. 这表明与MS相关的ON影响着两只眼睛,即使没有其他眼睛的直接ON史.
科学领域:
- 眼科医生 眼科 眼科
- 神经科学是一个神经科学.
- 视网膜成像 视网膜成像
背景情况:
- 众所周知,与多发性硬化症 (MS) 相关的视神经炎 (ON) 会导致视网膜内层变薄.
- 与MS相关的单边ON对未受影响的同眼的影响尚不清楚.
研究的目的:
- 为了比较多发性硬化眼睛的黄斑视网膜层厚度与单边的ON (MSON),他们的未受影响的眼睛,以及没有ON史的MS参与者 (MSnON).
主要方法:
- 横截面查研究涉及101名MSON和106名MSnON参与者.
- 光学连贯断层扫描 (OCT) 用于在标准化区域测量黄斑视网膜层厚度.
- 在MSON受影响的眼睛,MSON不受影响的眼睛和MSnON参与者之间进行了测量比较.
主要成果:
- 与MSnON参与者相比,MSnON参与者的未受影响的眼睛表现出更薄的内视网膜层 (视网膜神经纤维层,质细胞层,内状层).
- 受影响的MSON眼睛的视网膜内层比不受影响的眼睛和MSnON参与者都明显较薄.
- 与其他眼睛相比,MSON眼睛在特定的斑点区域呈现出更厚的内核和外视网膜层.
结论:
- 建议对MS患者进行双边检查和OCT成像,这些患者有单边急性ON.
- 在MSON患者中,未受影响的逆侧眼具有更薄的内视网膜层,需要监测.
- 这些发现突显了MS相关的ON对同眼的亚临床影响.
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