洞察功能性Pediococcus acidilactici SWU-HX39在缓解高尿路血症的潜在机制
Juxin He1, Xirui Zhang1, Huijing Chen1
1College of Food Science, Southwest University, Chinese-Hungarian Cooperative Research Centre for Food Science, Chongqing 400715, China. 1451320169@qq.com.
在小鼠模型中,Pediococcus acidilactici SWU-HX39 (HX39) 益生菌有效降低高尿酸 (HUA) 水平和肝酶活性. HX39还可以改善肠道微生物平衡,减少炎症,并保护脏免受损伤.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 超尿血症 (HUA) 给公共卫生带来了挑战,传统治疗会引起副作用.
- 益生菌显示出降低血清尿酸 (UA) 水平的潜力,但特定菌株需要进一步调查.
研究的目的:
- 为了评估Pediococcus acidilactici SWU-HX39 (HX39) 在体外和体内抗高尿血症 (HUA) 的疗效.
- 在HUA小鼠模型中,研究HX39对肝脏氨酸氧化酶 (XOD) 活性,炎症和肠道微生物群的调节作用.
主要方法:
- 在体外评估HX39的抗HUA特性.
- 建立一个HUA小鼠模型,由高精氨酸饮食诱导.
- 血清UA,肝脏XOD活性,促炎性细胞因子,脂多糖 (LPS) 和肠道微生物群组成的分析.
- 评估损伤和新陈代谢.
主要成果:
- 在HUA小鼠模型中,HX39显著降低了49.8%的血清UA和46.76%的肝XOD活性.
- HX39调节了肠道微生物群,减少了细菌类和准细菌类,同时增加了Eubacterium_brachy_group和norank_f_Ruminococcaceae.
- HX39缓解了炎症,改善了代谢,并显著减少了损伤.
结论:
- Pediococcus acidilactici SWU-HX39 显示出强大的抗高尿血症作用.
- HX39的治疗潜力在于其调节肝脏XOD,调节肠道微生物群,减少炎症和保护功能的能力.
- HX39在治疗HUA及其并发症方面表现有前途.
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