在减肥手术后肠道微生物群结构变化的元分析
Min Chen1, Tai-Chun Tang1, Yao-Yao Chen2
1Department of Colorectal Diseases/Clinical Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
International journal of surgery (London, England)
|July 22, 2025
概括
减肥手术增加了肠道微生物的多样性. 特定的细菌群如Akkermansia和Bacteroides增加,而Bifidobacterium和Lactobacillus在某些程序后减少,这表明潜在的益生菌益处.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 手术科学 手术科学
背景情况:
- 肥胖是一个普遍存在的健康问题,由减肥手术来管理.
- 减肥手术对肠道微生物群的确切影响仍然不完全理解.
- 肠道微生物群在宿主新陈代谢和整体健康中起着至关重要的作用.
研究的目的:
- 系统地审查和元分析腹手术后肠道微生物群组成的变化.
- 评估微生物多样性和关键细菌种群的相对丰度的变化.
- 确定可能导致研究结果异质性的因素.
主要方法:
- 在PubMed,Embase,Web of Science和Cochrane图书馆进行全面的文献搜索,截至2024年10月.
- 包括随机对照试验 (RCT) 和观察性研究,报告手术前后肠道微生物群数据.
- 使用Cochrane偏差风险工具和纽卡斯尔-太华尺度 (NOS) 评估研究偏差;通过随机效应模型进行数据合成.
主要成果:
- 包含了45项研究,其中大多数表明质量足够好.
- 手术后观察到阿尔法多样性的显著增加 (Chao和Shannon指数),尽管异质性很高.
- 特定的品种如Akkermansia,Bacteroides,Streptococcus和Veillonella增加,而Laparoscopic Sleeve Gastrectomy (LSG) 后的Bifidobacterium和Lactobacillus则下降. 在这种情况下,这些细菌的数量可能会增加.
结论:
- 腹腔外科手术显然可以增强肠道微生物群的α多样性.
- 显著的基因级转变表明有针对性益生菌干预的潜力,特别是在LSG后.
- 高异质性需要进一步研究,以阐明手术程序和特定微生物种群之间的因果关系.
相关概念视频
Anatomy of the Intestines
74.1K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
74.1K
Inflammatory Bowel Disease V: Surgical Management
219
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
219
Bacterial Flora of the Large Intestine
651
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
651


