肌肉骨疾病的全球宏观经济负担
Kaijie Qiu1,2,3,4, Canlong Wang1,2,3,4, Xianan Mo1,2,3,4
1Department of Orthopedic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
International journal of surgery (London, England)
|July 22, 2025
概括
肌肉骨系统疾病 (MSDs) 在2021年造成全球经济损失近2.1万亿美元,腰部疼痛是其中最重要的贡献者. 高收入地区面临的负担最大,但所有地区都必须为未来的经济影响做好准备.
科学领域:
- 全球卫生经济学 全球卫生经济学
- 流行病学 流行病学
- 公共卫生政策 公共卫生政策
背景情况:
- 肌肉骨系统疾病 (MSDs) 是一个重大的全球健康挑战,具有重大,但未被报告的经济后果.
- 以前的研究还没有全面详细介绍全球不同地区各种MSD子类别的宏观经济负担.
研究的目的:
- 量化MSD及其子类别的宏观经济负担,包括类风湿关节炎,骨关节炎,腰痛,部疼痛,痛风等.
- 分析2021年183个国家和地区的负担.
主要方法:
- 利用了来自2019年和2021年全球疾病负担 (GBD) 数据库的MSD残疾调整寿命年 (DALY) 的数据.
- 综合购买力平价 (PPP) 调整后的国内生产总值 (GDP) 数据来自世界银行.
- 采用损失福利价值 (VLW) 方法来估计宏观经济损失,以2021年国际美元 (PPP调整) 表示结果.
主要成果:
- 2021年,MSD导致全球VLW达到2099.84亿美元,相当于全球GDP的1.41%.
- 腰部疼痛占VLW/GDP的最大份额 (43%),其次是其他MSD (27%) 和骨关节炎 (14%).
- 高收入地区承受了最高的经济负担 (占GDP的1.74%),而撒哈拉以南非洲承受了最低的负担 (0.65%);塞浦路斯和日本超过了GDP的2%.
结论:
- 肌关节疾病在全球范围内造成了相当大的经济负担,特别是在高收入国家,未来的影响预计将在低收入和中等收入地区增加.
- 腰部疼痛和其他MSD是整体疾病负担的主要驱动因素.
- 建议包括优先考虑高收入地区的具有成本效益的护理和康复,并加强低收入和中等收入地区的预防和医疗保健基础设施.
相关概念视频
Disorders of the Skeletal Muscle
1.1K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
1.1K
Bone Disorders
4.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.0K
Gross Anatomy of Skeletal Muscles
13.7K
The connective tissues play a significant role in arranging the muscle fibers into a hierarchical structure that forms a complete muscle. Consider a muscle like the bicep brachii, commonly called the bicep. This muscle comprises thousands of muscle fibers enclosed by a protective layer of connective tissue called the endomysium. The endomysium is primarily composed of reticular fibers, a type of thin collagen fiber. It allows the exchange of nutrients and waste products at the fiber level,...
13.7K
The Functions of the Skeletal System
4.4K
The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
4.4K
Relaxation of Skeletal Muscles
3.8K
The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
3.8K


