在含有银的酸中平衡抗菌活性和毒性:银纳米粒子合并方法的影响
Oguz Kaan Kucukosman1, Ayda Pourmostafa2, Elvan Dogan2
1Department of Chemistry, Rutgers University, 73 Warren Street, Newark, NJ 07102, USA.
Journal of materials chemistry. B
|July 22, 2025
概括
优化银纳米颗粒 (AgNP) 融入酸 (Hap) 增强了抗菌性质. 反向沉方法产生了具有优越抗菌活性和生物医学应用生物相容性的Ag-Hap复合材料.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 材料化学 材料化学
背景情况:
- 酸 (Hap) 具有有限的抗菌特性.
- 银纳米粒子 (AgNPs) 提供增强的抗菌疗效,但可以引起细胞毒性.
- 将AgNP整合到Hap中进行优化对于平衡抗菌活性和生物相容性至关重要.
研究的目的:
- 为了确定将银纳入酸 (Ag-Hap) 的最佳条件.
- 评估Ag-Hap属性上的不同银结合策略和银含量.
- 为了在Ag-Hap材料中实现抗菌有效性和生物相容性之间的平衡.
主要方法:
- 通过沉合成纯Hap,白银替代的Hap和Ag-Hap复合物.
- 使用不同的方法制备了两个Ag-Hap复合物:在纳米银中沉Hap (方法1) 和沉AgNPs成Hap悬浮物 (方法2).
- 使用XRD,SEM,EDS和FTIR进行特征材料;评估了抗菌活性和细胞毒性.
主要成果:
- 与离子银替代相比,将AgNP嵌入Hap矩阵显示出优越的抗菌增强.
- 通过逆沉 (方法2) 合成的Ag-Hap复合物显示出杀菌活性和细胞活性的最佳平衡.
- 方法2中的最佳银含量 (x = 0.2-0.3) 促进了AgNP均分散,持续抗菌作用,并将细胞毒性降到最低.
结论:
- 反向沉 (方法2) 是生产具有增强抗菌特性和生物相容性的Ag-Hap的有效策略.
- 优化的Ag-Hap配方为开发生物活性涂层和支架提供了一个有希望的方法.
- 这些材料适用于骨科,牙科和其他生物医学植入物应用,需要抗微生物有效性和结构稳定性.
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