BMI介导的不同运输方式与骨关节炎风险之间的因果关系:孟德尔的随机化和介导分析
Xiaoming Xie1,2, Kuayue Zhang3, Yuan Li3
1Beijing Massage Hospital, Beijing, China.
概括
像步行和骑自行车这样的活跃运输减少了骨关节炎 (OA) 的风险,而驾驶则增加了风险. 身体质量指数 (BMI) 部分调解了这些影响,突出了它在OA发展中的作用.
科学领域:
- 流行病学 流行病学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 与运输相关的体力活动对于慢性疾病管理至关重要.
- 之前关于运输方式和骨关节炎 (OA) 风险的研究已经产生了不一致的结果.
- 身体质量指数 (BMI) 与运输方式有关,是OA的一个重要风险因素.
研究的目的:
- 调查不同运输方式与OA之间的因果关系.
- 检查BMI在运输方式与OA之间的关联中扮演的调解角色.
- 使用门德尔的随机化 (MR) 和调解分析来进行可靠的因果推理.
主要方法:
- 使用反变量加权 (IVW) 方法进行两样,两步的MR分析.
- 全基因组关联研究 (GWAS) 对运输方式,BMI和OA的数据.
- 用加权中位数和MR-Egger回归进行补充分析;异质性和性测试.
主要成果:
- 步行,骑自行车和使用公共交通工具与OA风险有负相关性 (P < 0.05).
- 驾驶与OA风险有积极的关联 (OR = 1.19,P = 0.029).
- BMI部分调解了运输方式和OA之间的因果关系,调解比例从25.0%到69.6%不等.
结论:
- 基因预测的步行,骑自行车或公共交通的使用与OA风险降低有关.
- 通过遗传预测,驾驶会增加OA的风险.
- 体重指数介于运输方式与OA风险之间的因果关系的25%以上.
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