产前诊断的Chiari类型1形
Mariana Dandes1, Jerome Massardier2, Matthieu Vinchon3
1Service de Neurochirurgie Pédiatrique, Hôpital Femme-Mère-Enfant, Centre de Référence C MAVEM, Site Constitutif-Lyon, Université de Lyon, INSERM 1033 Lyon, France. mariana.dandes@yahoo.ro.
概括
这项研究报告了首次使用成像和生物标记物诊断Chiari 1形的产前诊断. 该案例表明,在产前诊断的孤立的Chiari 1形可以产生良性的产后结果.
科学领域:
- 神经科学是一个神经科学.
- 儿科神经学 儿科神经学
- 产前诊断 在产前诊断
背景情况:
- 奇亚里1型形在儿童中很常见.
- 以前没有报道过Chiari1型形的产前诊断.
- 这项研究解决了这一疾病产前诊断知识的差距.
研究的目的:
- 介绍第一个报告的 Chiari 1 型形产前诊断病例.
- 详细说明支持产前诊断的成像和生物发现.
- 描述出生后的临床和成像随访.
主要方法:
- 一名怀孕妇女因怀疑基于超声波的Chiari 2形而被转诊.
- 胎儿神经声谱和MRI被用来评估后的异常.
- 分析了α-fetoprotein和乙烯基胆化酶水平.
- 进行了产后MRI和48个月的临床随访.
主要成果:
- 产前超声波和核磁共振显示大脑桃体在大沟下方的外,与Chiari 1形一致.
- 没有检测到脊髓失色或其他相关异常.
- 产后MRI证实了奇亚里1型形.
- 在48个月的随访期间,孩子的发育正常,没有症状.
结论:
- 奇阿里1型形可以在产前使用成像和生物标记物进行诊断.
- 孕前诊断可能是孤立的奇亚里1型形.
- 这种情况可能会有一个良性的产后过程,当孤立时,就像这个案例所暗示的那样.
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