与吸烟有关的大动脉形化:动脉样硬化多民族研究 (MESA) 的结果
Salman Ansari1, Robert Trujillo2, Robyn L McClelland2
1California University of Science and Medicine - School of Medicine, Colton, CA, USA. salman.ansari@md.cusm.edu.
The international journal of cardiovascular imaging
|July 22, 2025
概括
吸烟与较高的大动脉门 (AAC) 分数有关. 吸烟者的AAC增加与心血管疾病事件和死亡率的风险增加有关.
科学领域:
- 心血管成像和流行病学
- 胸部成像和公共卫生
背景情况:
- 吸烟是心血管疾病 (CVD) 的已知危险因素之一.
- 虽然冠状动脉在吸烟者中得到了很好的研究,但大动脉门 (AAC) 的研究仍然较少.
- 了解吸烟者的AAC对于评估心血管风险至关重要.
研究的目的:
- 为了研究吸烟状态和大动脉门 (AAC) 水平之间的关联.
- 为了确定AAC是否是一个独立的预测器事件心血管疾病和死亡率的个人有吸烟史.
主要方法:
- 利用了MESA研究 (第5次考试,2010-2012) 的2,191名参与者的数据,他们接受了非对比性胸部CT扫描.
- 在CT扫描上使用Agatston方法量化大动脉门 (AAC).
- 采用多变量线性回归和Cox比例危险模型,根据人口和临床风险因素进行调整.
主要成果:
- 与从未吸烟者相比,目前吸烟者的日志AAC分数显著更高 (1.10日志Agatston单位更高).
- 与从未吸烟的人相比,前吸烟者也表现出较高的日志-AAC分数 (0.58日志-Agatston单位高).
- 每一个日志-阿加斯顿单位的AAC增加都与心血管疾病事件的风险增加20.6%和经常吸烟者死亡风险增加12%有关.
结论:
- 吸烟与大动脉门 (AAC) 负担的增加有显著的关联.
- AAC是一种有价值的成像生物标志物,可预测有吸烟史的个人发生的心血管事件和死亡率.
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