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Updated: Sep 14, 2025

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STAT1的氨酸酸化维护了肠道上皮质的完整性,并限制了干扰素中介的细胞毒性

Hozaifa Metwally1, Maha M Elbrashy1,2, Hisako Kayama3,4

  • 1Laboratory of Immune Regulation, The World Premier International Research Center Initiative Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.

Proceedings of the National Academy of Sciences of the United States of America
|July 22, 2025
PubMed
概括

在氨酸748的STAT1酸化保护肠上皮细胞 (IEC) 免受损伤和炎症. 这种适应增强了表皮的弹性,通过促进整合蛋白β4,独立于干扰素信号,保护肠道屏障的完整性.

关键词:
美国国家统计局 (STAT1)肠道上皮质是肠道上皮质.整合物是一种整合物.干扰子干扰子干扰子三氨酸的酸化.

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