在绝经后妇女中评估生殖特征,表观遗传衰老和死亡率
Qiaofeng Ye1, Aaliya Ahamed1, Idan Shalev1
1Department of Biobehavioral Health, The Pennsylvania State University, University Park, Pennsylvania, United States.
概括
生殖特征,特别是过早更年期,与女性更快的衰老和死亡率增加有关. 这种通过DunedinPoAm测量的加速衰老可能受到激素治疗使用的影响,并表明需要进行临床监测.
科学领域:
- 老年学是一门学科.
- 生殖内分泌学 生殖内分泌学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 进化论理论认为,繁殖和长寿之间存在一种权衡.
- 表观遗传钟 (PhenoAge,GrimAge,DunedinPoAm) 估计生物年龄,并预测健康寿命/死亡率.
- 了解生殖特征对衰老的影响对于妇女健康至关重要.
研究的目的:
- 研究不同生殖特征,表观遗传衰老和绝经后妇女的死亡率之间的关联.
- 为了确定特定的生殖模式是否与加速的生物衰老相关.
- 探索这些关系的潜在调解者和调节者.
主要方法:
- 潜在的个人资料分析从国家健康和营养检查调查数据 (N=770) 中确定了四个生殖个人资料.
- 用PhenoAge,GrimAge和DunedinPoAm.Am来评估表观遗传年龄.
- 分析了死亡风险和表观遗传衰老的调解.
主要成果:
- 过早更年期 (3类) 与加快衰老 (DunedinPoAm) 有关,但与表观遗传年龄 (PhenoAge,GrimAge) 不相关.
- 在使用女性激素的女性中,这种加速显著.
- 3类女性的死亡率更高,部分原因是加速的DunedinPoAm.
结论:
- 生殖特征,特别是过早更年期,与改变的表观遗传衰老轨迹有关.
- 衰老的速度 (DunedinPoAm) 可能比整体表观遗传年龄更敏感于生殖变异.
- 临床监测过早更年期的衰老速度和明智的激素治疗可以减轻健康风险.
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